Article
At least two different regions are involved in allelic imbalance on chromosome arm 16q in breast cancer.
Genes, chromosomes & cancer - 1 Feb 1994
Cleton-Jansen A M, Moerland E W, Kuipers-Dijkshoorn N J, Callen D F, Sutherland G R, Hansen B, Devilee P, Cornelisse C J
Abstract excerpt
Loss of heterozygosity (LOH) or allelic imbalance, the latter term referring to both loss and gain of an allele, on the long arm of chromosome 16 has been repeatedly found in cancers of, e.g., the breast and prostate. This indicates the presence of one or more tumor suppressor genes on 16q. To lo...
Topics
- Alleles
- Breast Neoplasms
- Chromosome Aberrations
- Chromosomes, Human, Pair 16
- Genes, Tumor Suppressor
- Genetic Markers
- Heterozygote
- Humans
- Oncogenes
- Polymorphism, Restriction Fragment Length
- Sequence Deletion