Article
Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer.
Nature genetics - 1 Apr 2005
Sun Xiaodong, Frierson Henry F, Chen Ceshi, Li Changling, Ran Qimei, Otto Kristen B, Cantarel Brandi L, Cantarel Brandi M, Vessella Robert L, Gao Allen C, Petros John, Miura Yutaka, Simons Jonathan W, Dong Jin-Tang
Abstract excerpt
Cancer often results from the accumulation of multiple genetic alterations. Although most malignancies are sporadic, only a small number of genes have been shown to undergo frequent mutations in sporadic cancers. The long arm of chromosome 16 is frequently deleted in human cancers, but the target gene for this deletion has not been identified. Here we report that ATBF1, which encodes a transcription factor that...
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