Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking.

doi:10.1371/journal.pone.0033513

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Article

Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking.

PloS one - 1 Jan 2012

Kapoor Manav, Wang Jen-Chyong, Bertelsen Sarah, Bucholz Kathy, Budde John P, Hinrichs Anthony, Agrawal Arpana, Brooks Andrew, Chorlian David, Dick Danielle, Hesselbrock Victor, Foroud Tatiana, Kramer John, Kuperman Samuel, Manz Niklas, Nurnberger John, Porjesz Bernice, Rice John, Tischfield Jay, Xuei Xiaoling, Schuckit Marc, Edenberg Howard J, Bierut Laura J, Goate Alison M

Abstract excerpt

Several genome-wide association and candidate gene studies have linked chromosome 15q24-q25.1 (a region including the CHRNA5-CHRNA3-CHRNB4 gene cluster) with alcohol dependence, nicotine dependence and smoking-related illnesses such as lung cancer and chronic obstructive pulmonary disease. To further examine the impact of these genes on the development of substance use disorders, we tested whether variants within...

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Identifiers

PMID: 22438940
DOI: 10.1371/journal.pone.0033513
PMCID: PMC3306405

Genes

CHRNB4
CHRNA3
CHRNA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking.PMID 22438940Read ↗

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