A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence.

doi:10.1016/j.biopsych.2008.04.018

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Article

A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence.

Biological psychiatry - 1 Dec 2008

Grucza Richard A, Wang Jen C, Stitzel Jerry A, Hinrichs Anthony L, Saccone Scott F, Saccone Nancy L, Bucholz Kathleen K, Cloninger C Robert, Neuman Rosalind J, Budde John P, Fox Louis, Bertelsen Sarah, Kramer John, Hesselbrock Victor, Tischfield Jay, Nurnberger John I, Almasy Laura, Porjesz Bernice, Kuperman Samuel, Schuckit Marc A, Edenberg Howard J, Rice John P, Goate Alison M, Bierut Laura J

Abstract excerpt

BACKGROUND: A nonsynonymous coding polymorphism, rs16969968, of the CHRNA5 gene that encodes the alpha-5 subunit of the nicotinic acetylcholine receptor (nAChR) has been found to be associated with nicotine dependence. The goal of this study was to examine the association of this variant with cocaine dependence. METHODS: Genetic association analysis was performed in two independent samples of unrelated case and...

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Identifiers

PMID: 18519132
DOI: 10.1016/j.biopsych.2008.04.018
PMCID: PMC2582594

Genes

CHRNA5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence.PMID 18519132Read ↗

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