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Article

Ornithine decarboxylase G316A genotype is prognostic for colorectal adenoma recurrence and predicts efficacy of aspirin chemoprevention.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2008

Hubner Richard A, Muir Kenneth R, Liu Jo-Fen, Logan Richard F A, Grainge Matthew J, Houlston Richard S

Abstract excerpt

PURPOSE: The chemopreventive activity of aspirin in colorectal neoplasia may be explained in part by its effect on polyamine metabolism. The ornithine decarboxylase (ODC) G316A polymorphism affects polyamine metabolism through altered expression of ODC. We investigated the influence of ODC G316A on the chemopreventive activity of aspirin in colorectal adenoma (CRA) recurrence. EXPERIMENTAL DESIGN: We genotyped...

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Source

Identifiers

PMID: 18413818
DOI: 10.1158/1078-0432.CCR-07-4599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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