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Article

Impact of genetic polymorphisms on adenoma recurrence and toxicity in a COX2 inhibitor (celecoxib) trial: results from a pilot study.

Pharmacogenetics and genomics - 1 Aug 2013

Kraus Sarah, Hummler Simone, Toriola Adetunji T, Poole Elizabeth M, Scherer Dominique, Kotzmann Jana, Makar Karen W, Kazanov Dina, Galazan Lior, Naumov Inna, Coghill Anna E, Duggan David, Gigic Biljana, Arber Nadir, Ulrich Cornelia M

Abstract excerpt

OBJECTIVE: Chemoprevention trials have shown that celecoxib reduces adenoma recurrence but can cause cardiovascular toxicity. In this pilot study, we evaluated associations between genetic variation in several candidate pathways (e.g. prostaglandin synthesis) and adenoma recurrence and cardiovascular and gastrointestinal toxicities. METHODS: Genotyping analysis was carried out on 117 Israeli colorectal adenoma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23778325
DOI: 10.1097/FPC.0b013e3283631784
PMCID: PMC4435676

Genes

SRC
ALOX12
CRP
GPX3
MAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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