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Article

Ornithine decarboxylase G316A genotype and colorectal cancer risk.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland - 1 Aug 2011

Hughes D J, Hlavatá I, Soucek P, Pardini B, Naccarati A, Vodickova L, O'Morain C, Vodicka P

Abstract excerpt

AIM: Ornithine decarboxylase (ODC) is a modifier of adenomatous polyposis coli-dependent tumourigenesis. The G316 > A polymorphism in intron 1 of the ODC gene lies between two myc-binding domains and alters the expression of the gene to affect polyamine metabolism. This variant may be associated with recurrence of colorectal adenoma. We examined whether this variant also modified the susceptibility to sporadic...

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PMID: 20456464
DOI: 10.1111/j.1463-1318.2010.02300.x

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