Cyclooxygenase-2 polymorphisms, aspirin treatment, and risk for colorectal adenoma recurrence--data from a randomized clinical trial.

doi:10.1158/1055-9965.EPI-09-0363

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Article

Cyclooxygenase-2 polymorphisms, aspirin treatment, and risk for colorectal adenoma recurrence--data from a randomized clinical trial.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 2009

Barry Elizabeth L, Sansbury Leah B, Grau Maria V, Ali Iqbal U, Tsang Shirley, Munroe David J, Ahnen Dennis J, Sandler Robert S, Saibil Fred, Gui Jiang, Bresalier Robert S, McKeown-Eyssen Gail E, Burke Carol, Baron John A

Abstract excerpt

Cyclooxygenase-2 (COX-2) catalyzes the rate-limiting step in the production of prostaglandins, potent mediators of inflammation. Chronic inflammation plays an important role in the development and progression of colorectal cancer. Aspirin inhibits COX-2 activity and lowers the risk for colorectal adenomas and cancer. We investigated whether common genetic variation in COX-2 influenced risk for colorectal adenoma...

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Identifiers

PMID: 19755647
DOI: 10.1158/1055-9965.EPI-09-0363
PMCID: PMC2769932

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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