Article
Ornithine decarboxylase polymorphism modification of response to aspirin treatment for colorectal adenoma prevention.
Journal of the National Cancer Institute - 18 Oct 2006
Barry Elizabeth L R, Baron John A, Bhat Shubha, Grau Maria V, Burke Carol A, Sandler Robert S, Ahnen Dennis J, Haile Robert W, O'Brien Thomas G
Abstract excerpt
BACKGROUND: Previous research suggests that the G315A single-nucleotide polymorphism in the ornithine decarboxylase (ODC) gene may be a genetic marker for risk of colorectal neoplasia and may also modify the association of aspirin use with risk. METHODS: We tested these hypotheses among participants in the Aspirin/Folate Polyp Prevention Study who were randomly assigned to placebo or to aspirin treatment (81 or...
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