Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene.

Proceedings of the National Academy of Sciences of the United States of America - 24 Jun 2003

Martinez Maria Elena, O'Brien Thomas G, Fultz Kimberly E, Babbar Naveen, Yerushalmi Hagit, Qu Ning, Guo Yongjun, Boorman David, Einspahr Janine, Alberts David S, Gerner Eugene W

Abstract excerpt

Most sporadic colon adenomas acquire mutations in the adenomatous polyposis coli gene (APC) and show defects in APC-dependent signaling. APC influences the expression of several genes, including the c-myc oncogene and its antagonist Mad1. Ornithine decarboxylase (ODC), the first enzyme in polyami...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma
Share to Anti-Inflammatory Agents, Non-Steroidal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aspirin

Share to Colonic Neoplasms

Share to Ornithine Decarboxylase

Share to Polyamines

Share to Recurrence

Source

Open in PubMed Open full text

Identifiers

PMID: 12810952
DOI: 10.1073/pnas.1332465100
PMCID: PMC164678

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12810952-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene.PMID 12810952Read ↗

Ornithine decarboxylase G316A genotype is prognostic for colorectal adenoma recurrence and predicts efficacy of aspirin chemoprevention.Semantic proximity Read ↗

Variants downstream of the ornithine decarboxylase gene influence risk of colorectal adenoma and aspirin chemoprevention.Semantic proximity Read ↗

Ornithine decarboxylase-1 polymorphism, chemoprevention with eflornithine and sulindac, and outcomes among colorectal adenoma patients.Semantic proximity Read ↗

Ornithine decarboxylase polymorphism modification of response to aspirin treatment for colorectal adenoma prevention.Semantic proximity Read ↗

Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival.Semantic proximity Read ↗

Ornithine decarboxylase G316A genotype and colorectal cancer risk.Semantic proximity Read ↗

Polyamines as mediators of APC-dependent intestinal carcinogenesis and cancer chemoprevention.Semantic proximity Read ↗

A comprehensive strategy to combat colon cancer targeting the adenomatous polyposis coli tumor suppressor gene.Semantic proximity Read ↗

Cyclooxygenase-2 polymorphisms, aspirin treatment, and risk for colorectal adenoma recurrence--data from a randomized clinical trial.Semantic proximity Read ↗

Dietary polyamine intake and risk of colorectal adenomatous polyps.Semantic proximity Read ↗

Aspirin use, 8q24 single nucleotide polymorphism rs6983267, and colorectal cancer according to CTNNB1 alterations.Semantic proximity Read ↗

Combination chemoprevention for colon cancer targeting polyamine synthesis and inflammation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.