Article
Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations.
PloS one - 1 Jan 2018
Sheth Harsh, Northwood Emma, Ulrich Cornelia M, Scherer Dominique, Elliott Faye, Barrett Jennifer H, Forman David, Wolf C Roland, Smith Gillian, Jackson Michael S, Santibanez-Koref Mauro, Haile Robert, Casey Graham, Jenkins Mark, Win Aung Ko, Hopper John L, Marchand Loic Le, Lindor Noralane M, Thibodeau Stephen N, Potter John D, Burn John, Bishop D Timothy
Abstract excerpt
Regular aspirin use is associated with reduced risk of colorectal cancer (CRC). Variation in aspirin's chemoprevention efficacy has been attributed to the presence of single nucleotide polymorphisms (SNPs). We conducted a meta-analysis using two large population-based case-control datasets, the UK-Leeds Colorectal Cancer Study Group and the NIH-Colon Cancer Family Registry, having a combined total of 3325 cases...
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