Mus81-Eme1 and Rqh1 involvement in processing stalled and collapsed replication forks.

doi:10.1074/jbc.M202120200

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Article

Mus81-Eme1 and Rqh1 involvement in processing stalled and collapsed replication forks.

The Journal of biological chemistry - 6 Sept 2002

Doe Claudette L, Ahn Jong Sook, Dixon Julie, Whitby Matthew C

Abstract excerpt

The processing of stalled replication forks and the repair of collapsed replication forks are essential functions in all organisms. In fission yeast DNA junctions at stalled replication forks appear to be processed by either the Rqh1 DNA helicase or Mus81-Eme1 endonuclease. Accordingly, we show that the hypersensitivity to agents that cause replication fork stalling of mus81, eme1, and rqh1 mutants is suppressed...

Topics

Camptothecin
Cell Nucleus
DNA
DNA Helicases
DNA Replication
DNA-Binding Proteins
Dose-Response Relationship, Drug
Endodeoxyribonucleases
Endonucleases
Escherichia coli
Escherichia coli Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Holliday Junction Resolvases

Mutation

Plasmids

Recombinant Proteins

Saccharomyces cerevisiae Proteins

Schizosaccharomyces pombe Proteins

Substrate Specificity

Source

Open in PubMed

Identifiers

PMID: 12084712
DOI: 10.1074/jbc.M202120200

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Mus81-Eme1 and Rqh1 involvement in processing stalled and collapsed replication forks.PMID 12084712Read ↗

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