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Article

Mus81-Eme1 and Rqh1 involvement in processing stalled and collapsed replication forks.

The Journal of biological chemistry - 6 Sept 2002

Doe Claudette L, Ahn Jong Sook, Dixon Julie, Whitby Matthew C

Abstract excerpt

The processing of stalled replication forks and the repair of collapsed replication forks are essential functions in all organisms. In fission yeast DNA junctions at stalled replication forks appear to be processed by either the Rqh1 DNA helicase or Mus81-Eme1 endonuclease. Accordingly, we show that the hypersensitivity to agents that cause replication fork stalling of mus81, eme1, and rqh1 mutants is suppressed...

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Identifiers

PMID: 12084712
DOI: 10.1074/jbc.M202120200

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Mus81-Eme1 and Rqh1 involvement in processing stalled and collapsed replication forks.PMID 12084712Read ↗

Cleavage of stalled forks by fission yeast Mus81/Eme1 in absence of DNA replication checkpoint.Semantic proximity Read ↗

Mus81 is essential for sister chromatid recombination at broken replication forks.Semantic proximity Read ↗

Partial suppression of the fission yeast rqh1(-) phenotype by expression of a bacterial Holliday junction resolvase.Semantic proximity Read ↗

The endogenous Mus81-Eme1 complex resolves Holliday junctions by a nick and counternick mechanism.Semantic proximity Read ↗

Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress.Semantic proximity Read ↗

A winged helix domain in human MUS81 binds DNA and modulates the endonuclease activity of MUS81 complexes.Semantic proximity Read ↗

Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint.Semantic proximity Read ↗

Crystal structure of the Mus81-Eme1 complex.Semantic proximity Read ↗

MUS81-EME2 Promotes Replication Fork RestartSemantic proximity Read ↗

Holliday junctions in the eukaryotic nucleus: resolution in sight?Semantic proximity Read ↗

Single Holliday junctions are intermediates of meiotic recombination.Semantic proximity Read ↗

DNA repair by a Rad22-Mus81-dependent pathway that is independent of Rhp51.Semantic proximity Read ↗

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