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Article

The endogenous Mus81-Eme1 complex resolves Holliday junctions by a nick and counternick mechanism.

Molecular cell - 1 Sept 2003

Gaillard Pierre-Henri L, Noguchi Eishi, Shanahan Paul, Russell Paul

Abstract excerpt

Functional studies strongly suggest that the Mus81-Eme1 complex resolves Holliday junctions (HJs) in fission yeast, but in vitro it preferentially cleaves flexible three-way branched structures that model replication forks or 3' flaps. Here we report that a nicked HJ is the preferred substrate of endogenous and recombinant Mus81-Eme1. Cleavage occurs specifically on the strand that opposes the nick, resulting in...

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Identifiers

PMID: 14527419
DOI: 10.1016/s1097-2765(03)00342-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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