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Article

DNA Damage and Its Role in Cancer Therapeutics.

International journal of molecular sciences - 1 Mar 2023

Moon Jaeyoung, Kitty Ichiwa, Renata Kusuma, Qin Sisi, Zhao Fei, Kim Wootae

Abstract excerpt

DNA damage is a double-edged sword in cancer cells. On the one hand, DNA damage exacerbates gene mutation frequency and cancer risk. Mutations in key DNA repair genes, such as breast cancer 1 (BRCA1) and/or breast cancer 2 (BRCA2), induce genomic instability and promote tumorigenesis. On the other hand, the induction of DNA damage using chemical reagents or radiation kills cancer cells effectively....

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Identifiers

PMID: 36902170
DOI: 10.3390/ijms24054741
PMCID: PMC10003233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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