Inhibiting the<scp>DNA</scp>damage response as a therapeutic manoeuvre in cancer

Abstract excerpt

UNLABELLED: The DNA damage response (DDR), consisting of an orchestrated network of proteins effecting repair and signalling to cell cycle arrest, to allow time to repair, is essential for cell viability and to prevent DNA damage being passed on to daughter cells. The DDR is dysregulated in cancer with some pathways up-regulated and others down-regulated or lost. Up-regulated pathways can confer resistance to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer-related Molecular Pathways
• Share to Cancer therapeutics and mechanisms
• Share to DNA Repair Mechanisms