Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Therapeutic Targeting of DNA Replication Stress in Cancer

26 Jun 2023

Abstract excerpt

This article reviews the currently used therapeutic strategies to target DNA replication stress for cancer treatment in the clinic, highlighting their effectiveness and limitations due to toxicity and drug resistance. Cancer cells experience enhanced spontaneous DNA damage due to compromised DNA replication machinery, elevated levels of reactive oxygen species, loss of tumor suppressor genes, and/or constitutive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer therapeutics and mechanisms
Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37510250
DOI: 10.3390/genes14071346

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Therapeutic Targeting of DNA Replication Stress in CancerPMID 37510250Read ↗

Targeting DNA Replication Stress for Cancer TherapySemantic proximity Read ↗

DNA replication stress and cancer chemotherapySemantic proximity Read ↗

Exploiting DNA Replication Stress as a Therapeutic Strategy for Breast CancerSemantic proximity Read ↗

DNA replication stress and cancer: cause or cure?Semantic proximity Read ↗

Targeting Replication Stress Response Pathways to Enhance Genotoxic Chemo- and RadiotherapySemantic proximity Read ↗

DNA replication stress as a hallmark of cancer.Semantic proximity Read ↗

DNA replication stress: oncogenes in the spotlightSemantic proximity Read ↗

DNA replication stress: oncogenes in the spotlightSemantic proximity Read ↗

Amplifying tumour-specific replication lesions by DNA repair inhibitors - a new era in targeted cancer therapy.Semantic proximity Read ↗

Precision Oncology with Drugs Targeting the Replication Stress, ATR, and Schlafen 11Semantic proximity Read ↗

Uracil-induced replication stress drives mutations, genome instability, anti-cancer treatment efficacy, and resistanceSemantic proximity Read ↗

Identification of critical factors of the replication stress response in human cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.