Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Haplotype reconstruction error as a classical misclassification problem: introducing sensitivity and specificity as error measures.

PloS one - 26 Mar 2008

Lamina Claudia, Bongardt Friedhelm, Küchenhoff Helmut, Heid Iris M

Abstract excerpt

BACKGROUND: Statistically reconstructing haplotypes from single nucleotide polymorphism (SNP) genotypes, can lead to falsely classified haplotypes. This can be an issue when interpreting haplotype association results or when selecting subjects with certain haplotypes for subsequent functional studies. It was our aim to quantify haplotype reconstruction error and to provide tools for it. METHODS AND RESULTS: By...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genotype
Share to Haplotypes
Share to Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Sensitivity and Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 18365008
DOI: 10.1371/journal.pone.0001853
PMCID: PMC2267219

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Haplotype reconstruction error as a classical misclassification problem: introducing sensitivity and specificity as error measures.PMID 18365008Read ↗

Haplotype misclassification resulting from statistical reconstruction and genotype error, and its impact on association estimates.Semantic proximity Read ↗

[How about the uncertainty in the haplotypes in the population-based KORA studies?].Semantic proximity Read ↗

Quantifying bias due to allele misclassification in case-control studies of haplotypes.Semantic proximity Read ↗

LRTae: improving statistical power for genetic association with case/control data when phenotype and/or genotype misclassification errors are present.Semantic proximity Read ↗

How to link call rate and p-values for Hardy-Weinberg equilibrium as measures of genome-wide SNP data quality.Semantic proximity Read ↗

Simple estimates of haplotype relative risks in case-control data.Semantic proximity Read ↗

Accounting for haplotype uncertainty in matched association studies: a comparison of simple and flexible techniques.Semantic proximity Read ↗

Haplotype frequency estimation in the presence of genotyping errors.Semantic proximity Read ↗

A comparison of tagging methods and their tagging space.Semantic proximity Read ↗

Impact of genotyping errors on the type I error rate and the power of haplotype-based association methods.Semantic proximity Read ↗

Haplotype reconstruction for genetically complex regions with ambiguous genotype calls: Illustration by the KIR gene region.Semantic proximity Read ↗

The impact of genotyping error on haplotype reconstruction and frequency estimation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.