Haplotype reconstruction error as a classical misclassification problem: introducing sensitivity and specificity as error measures.

doi:10.1371/journal.pone.0001853

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Article

Haplotype reconstruction error as a classical misclassification problem: introducing sensitivity and specificity as error measures.

PloS one - 26 Mar 2008

Lamina Claudia, Bongardt Friedhelm, Küchenhoff Helmut, Heid Iris M

Abstract excerpt

BACKGROUND: Statistically reconstructing haplotypes from single nucleotide polymorphism (SNP) genotypes, can lead to falsely classified haplotypes. This can be an issue when interpreting haplotype association results or when selecting subjects with certain haplotypes for subsequent functional stu...

Topics

Genotype
Haplotypes
Humans
Polymorphism, Single Nucleotide
Sensitivity and Specificity

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