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Article

Accounting for haplotype uncertainty in matched association studies: a comparison of simple and flexible techniques.

Genetic epidemiology - 1 Apr 2005

Kraft Peter, Cox David G, Paynter Randi A, Hunter David, De Vivo Immaculata

Abstract excerpt

Population-based case-control studies measuring associations between haplotypes of single nucleotide polymorphisms (SNPs) are increasingly popular, in part because haplotypes of a few "tagging" SNPs may serve as surrogates for variation in relatively large sections of the genome. Due to current technological limitations, haplotypes in cases and controls must be inferred from unphased genotypic data. Using...

Topics

Algorithms
Alleles
Bayes Theorem
Case-Control Studies
Computer Simulation
Endometrial Neoplasms
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Logistic Models

Models, Genetic

Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 15637718
DOI: 10.1002/gepi.20061

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15637718-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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