Article
Quantifying bias due to allele misclassification in case-control studies of haplotypes.
Genetic epidemiology - 1 Nov 2006
Govindarajulu Usha S, Spiegelman Donna, Miller Katie L, Kraft Peter
Abstract excerpt
OBJECTIVES: Genotyping errors can induce biases in frequency estimates for haplotypes of single nucleotide polymorphisms (SNPs). Here, we considered the impact of SNP allele misclassification on haplotype odds ratio estimates from case-control studies of unrelated individuals. METHODS: We calculated bias analytically, using the haplotype counts expected in cases and controls under genotype misclassification. We...
Topics
- Alleles
- Bias
- Case-Control Studies
- Genotype
- Haplotypes
- Humans
- Models, Genetic
- Odds Ratio
- Polymorphism, Single Nucleotide