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Article

Impact of genotyping errors on the type I error rate and the power of haplotype-based association methods.

BMC genetics - 29 Jan 2009

Marquard Vivien, Beckmann Lars, Heid Iris M, Lamina Claudia, Chang-Claude Jenny

Abstract excerpt

BACKGROUND: We investigated the influence of genotyping errors on the type I error rate and empirical power of two haplotype based association methods applied to candidate regions. We compared the performance of the Mantel Statistic Using Haplotype Sharing and the haplotype frequency based score test with that of the Armitage trend test.Our study is based on 1000 replication of simulated case-control data...

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Identifiers

PMID: 19178712
DOI: 10.1186/1471-2156-10-3
PMCID: PMC2648998

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