Article
The impact of genotyping error on haplotype reconstruction and frequency estimation.
European journal of human genetics : EJHG - 1 Oct 2002
Kirk Katherine M, Cardon Lon R
Abstract excerpt
The choice of genotyping families vs unrelated individuals is a critical factor in any large-scale linkage disequilibrium (LD) study. The use of unrelated individuals for such studies is promising, but in contrast to family designs, unrelated samples do not facilitate detection of genotyping errors, which have been shown to be of great importance for LD and linkage studies and may be even more important in...
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