Article
Haplotype misclassification resulting from statistical reconstruction and genotype error, and its impact on association estimates.
Annals of human genetics - 1 Sept 2010
Lamina Claudia, Küchenhoff Helmut, Chang-Claude Jenny, Paulweber Bernhard, Wichmann H-Erich, Illig Thomas, Hoehe Margret R, Kronenberg Florian, Heid Iris M
Abstract excerpt
Haplotypes are an important concept for genetic association studies, but involve uncertainty due to statistical reconstruction from single nucleotide polymorphism (SNP) genotypes and genotype error. We developed a re-sampling approach to quantify haplotype misclassification probabilities and impl...
Topics
- Adiponectin
- Body Mass Index
- Genetic Association Studies
- Genotype
- Haplotypes
- Humans
- Models, Genetic
- Sensitivity and Specificity