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Article

How to link call rate and p-values for Hardy-Weinberg equilibrium as measures of genome-wide SNP data quality.

Statistics in medicine - 30 Sept 2010

Finner Helmut, Strassburger Klaus, Heid Iris M, Herder Christian, Rathmann Wolfgang, Giani Guido, Dickhaus Thorsten, Lichtner Peter, Meitinger Thomas, Wichmann H-Erich, Illig Thomas, Gieger Christian

Abstract excerpt

We study the link between two quality measures of SNP (single nucleotide polymorphism) data in genome-wide association (GWA) studies, that is, per SNP call rates (CR) and p-values for testing Hardy-Weinberg equilibrium (HWE). The aim is to improve these measures by applying methods based on realized randomized p-values, the false discovery rate and estimates for the proportion of false hypotheses. While exact...

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PMID: 20641143
DOI: 10.1002/sim.4004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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