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Article

LRTae: improving statistical power for genetic association with case/control data when phenotype and/or genotype misclassification errors are present.

BMC genetics - 27 Apr 2006

Barral Sandra, Haynes Chad, Stone Millicent, Gordon Derek

Abstract excerpt

BACKGROUND: In the field of statistical genetics, phenotype and genotype misclassification errors can substantially reduce power to detect association with genetic case/control studies. Misclassification also can bias population frequency parameters such as genotype, haplotype, or multi-locus genotype frequencies. These problems are of particular concern in case/control designs because, short of repeated...

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PMID: 16689984
DOI: 10.1186/1471-2156-7-24
PMCID: PMC1471798

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