Article
LRTae: improving statistical power for genetic association with case/control data when phenotype and/or genotype misclassification errors are present.
BMC genetics - 27 Apr 2006
Barral Sandra, Haynes Chad, Stone Millicent, Gordon Derek
Abstract excerpt
BACKGROUND: In the field of statistical genetics, phenotype and genotype misclassification errors can substantially reduce power to detect association with genetic case/control studies. Misclassification also can bias population frequency parameters such as genotype, haplotype, or multi-locus genotype frequencies. These problems are of particular concern in case/control designs because, short of repeated...
Topics
- Case-Control Studies
- Data Interpretation, Statistical
- Genetics, Population
- Genotype
- Humans
- Models, Genetic
- Models, Statistical
- Phenotype
- Reproducibility of Results
- Research Design