Article
Cardiovascular consequences of a polygenetic component of blood pressure in an urban-based longitudinal study: the Malmö diet and cancer.
Journal of hypertension - 1 Jul 2014
Fava Cristiano, Ohlsson Therese, Sjögren Marketa, Tagetti Angela, Almgren Peter, Engström Gunnar, Nilsson Peter, Hedblad Bo, Minuz Pietro, Melander Olle
Abstract excerpt
BACKGROUND: A recently published genome wide association study identified 29 single nucleotide polymorphisms (SNPs) influencing blood pressure (BP). Case-control studies suggest that a genetic risk score (GRS) based on these 29 SNPs affect the risk of cardiovascular disease (CVD), but its role for CVD at population level is unknown. Here, we prospectively evaluate the impact of this polygenetic BP component on...
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