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Influence of common genetic variation on blood lipid levels, cardiovascular risk, and coronary events in two British prospective cohort studies.

European heart journal - 1 Apr 2013

Shah Sonia, Casas Juan P, Gaunt Tom R, Cooper Jackie, Drenos Fotios, Zabaneh Delilah, Swerdlow Daniel I, Shah Tina, Sofat Reecha, Palmen Jutta, Kumari Meena, Kivimaki Mika, Ebrahim Shah, Smith George Davey, Lawlor Debbie A, Talmud Philippa J, Whittaker John, Day Ian N M, Hingorani Aroon D, Humphries Steve E

Abstract excerpt

AIMS: The aim of this study was to quantify the collective effect of common lipid-associated single nucleotide polymorphisms (SNPs) on blood lipid levels, cardiovascular risk, use of lipid-lowering medication, and risk of coronary heart disease (CHD) events. METHODS AND RESULTS: Analysis was performed in two prospective cohorts: Whitehall II (WHII; N = 5059) and the British Women's Heart and Health Study (BWHHS;...

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Cardiovascular Diseases
Cholesterol, HDL
Cholesterol, LDL
Coronary Disease

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Hyperlipidemias

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PMID: 22977227
DOI: 10.1093/eurheartj/ehs243
PMCID: PMC3612774

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