Article
Marginal role for 53 common genetic variants in cardiovascular disease prediction.
Heart (British Cardiac Society) - 15 Oct 2016
Morris Richard W, Cooper Jackie A, Shah Tina, Wong Andrew, Drenos Fotios, Engmann Jorgen, McLachlan Stela, Jefferis Barbara, Dale Caroline, Hardy Rebecca, Kuh Diana, Ben-Shlomo Yoav, Wannamethee S Goya, Whincup Peter H, Casas Juan-Pablo, Kivimaki Mika, Kumari Meena, Talmud Philippa J, Price Jacqueline F, Dudbridge Frank, Hingorani Aroon D, Humphries Steve E
Abstract excerpt
OBJECTIVE: We investigated discrimination and calibration of cardiovascular disease (CVD) risk scores when genotypic was added to phenotypic information. The potential of genetic information for those at intermediate risk by a phenotype-based risk score was assessed. METHODS: Data were from seven prospective studies including 11 851 individuals initially free of CVD or diabetes, with 1444 incident CVD events over...
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