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Article

Common single-nucleotide polymorphisms act in concert to affect plasma levels of high-density lipoprotein cholesterol.

American journal of human genetics - 1 Dec 2007

Spirin Victor, Schmidt Steffen, Pertsemlidis Alexander, Cooper Richard S, Cohen Jonathan C, Sunyaev Shamil R

Abstract excerpt

The identification of DNA sequence variants underlying human complex phenotypes remains a significant challenge for several reasons: individual variants can have small phenotypic effects or low population frequencies, and multiple allelic variants may act in concert to affect a trait. We evaluated the combined effect of allelic variants in seven genes involved in high-density lipoprotein (HDL) metabolism, using...

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Identifiers

PMID: 17952847
DOI: 10.1086/522497
PMCID: PMC2276349

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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