Recombinase-deficient T cell development by selective accumulation of CD3 into lipid rafts.

doi:10.1002/eji.200737917

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Article

Recombinase-deficient T cell development by selective accumulation of CD3 into lipid rafts.

European journal of immunology - 1 Apr 2008

Ferrera Denise, Panigada Maddalena, Porcellini Simona, Grassi Fabio

Abstract excerpt

The pre-T cell receptor (pre-TCR) promotes the development of thymocytes with productive rearrangement at the TCR beta chain locus by signaling in a ligand-independent fashion. The TCR beta chain associates with the invariant pre-Talpha (pTalpha) chain, which bears specific charged residues in the extracellular portion mediating pre-TCR self-oligomerization. In recombinase-deficient thymocytes, calnexin (CNX)...

Topics

Animals
CD3 Complex
Calnexin
Cell Differentiation
Cells, Cultured
Lipoylation
Membrane Microdomains
Membrane Proteins
Mice
Mutation
Protein Binding
Recombinases
T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 18350545
DOI: 10.1002/eji.200737917

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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