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Article

Function of the pre-T-cell receptor alpha chain in T-cell development and allelic exclusion at the T-cell receptor beta locus.

Proceedings of the National Academy of Sciences of the United States of America - 5 Mar 1996

Xu Y, Davidson L, Alt F W, Baltimore D

Abstract excerpt

The pre-T-cell receptor, composed of the T-cell receptor (TCR) beta chain (TCRbeta), pre-Talpha (pTalpha) chain, and CD3 molecules, has been postulated to be a transducer of signals during the early stages of T-cell development. To examine the function of the transmembrane pTalpha chain during tbymocyte development, we generated pTalpha-/- embryonic stem cells and assayed their ability to differentiate into...

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Identifiers

PMID: 8700903
DOI: 10.1073/pnas.93.5.2169
PMCID: PMC39929

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Related research

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Function of the pre-T-cell receptor alpha chain in T-cell development and allelic exclusion at the T-cell receptor beta locus.PMID 8700903Read ↗

Crucial function of the pre-T-cell receptor (TCR) in TCR beta selection, TCR beta allelic exclusion and alpha beta versus gamma delta lineage commitment.Semantic proximity Read ↗

Allelic exclusion in pTalpha-deficient mice: no evidence for cell surface expression of two T cell receptor (TCR)-beta chains, but less efficient inhibition of endogeneous Vbeta--> (D)Jbeta rearrangements in the presence of a functional TCR-beta transgene.Semantic proximity Read ↗

Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor beta locus.Semantic proximity Read ↗

TCRbeta transmembrane tyrosines are required for pre-TCR function.Semantic proximity Read ↗

The Ets-1 transcription factor is required for complete pre-T cell receptor function and allelic exclusion at the T cell receptor beta locus.Semantic proximity Read ↗

Pleiotropic changes controlled by the pre-T-cell receptor.Semantic proximity Read ↗

The biological activity of natural and mutant pTalpha alleles.Semantic proximity Read ↗

The CD3-gammadeltaepsilon and CD3-zeta/eta modules are each essential for allelic exclusion at the T cell receptor beta locus but are both dispensable for the initiation of V to (D)J recombination at the T cell receptor-beta, -gamma, and -delta loci.Semantic proximity Read ↗

Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages.Semantic proximity Read ↗

Regulation of TCR alpha and beta gene allelic exclusion during T-cell development.Semantic proximity Read ↗

Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for beta-selection and TCR repertoire formation.Semantic proximity Read ↗

A critical lineage-nonspecific role for pTalpha in mediating allelic and isotypic exclusion in TCRbeta-transgenic mice.Semantic proximity Read ↗

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