Article
Function of the pre-T-cell receptor alpha chain in T-cell development and allelic exclusion at the T-cell receptor beta locus.
Proceedings of the National Academy of Sciences of the United States of America - 5 Mar 1996
Xu Y, Davidson L, Alt F W, Baltimore D
Abstract excerpt
The pre-T-cell receptor, composed of the T-cell receptor (TCR) beta chain (TCRbeta), pre-Talpha (pTalpha) chain, and CD3 molecules, has been postulated to be a transducer of signals during the early stages of T-cell development. To examine the function of the transmembrane pTalpha chain during tb...
Topics
- Alleles
- Animals
- Base Sequence
- Cell Differentiation
- DNA Primers
- Gene Expression Regulation, Developmental
- Hematopoiesis
- Heterozygote
- Mice
- Mice, Knockout
- Molecular Sequence Data
- Receptors, Antigen, T-Cell, alpha-beta
- T-Lymphocytes