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Article

SIRT1 contributes to telomere maintenance and augments global homologous recombination

27 Dec 2010

Abstract excerpt

Yeast Sir2 deacetylase is a component of the silent information regulator (SIR) complex encompassing Sir2/Sir3/Sir4. Sir2 is recruited to telomeres through Rap1, and this complex spreads into subtelomeric DNA via histone deacetylation. However, potential functions at telomeres for SIRT1, the mammalian orthologue of yeast Sir2, are less clear. We studied both loss of function (SIRT1 deficient) and gain of function...

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PMID: 21187328
DOI: 10.1083/jcb.201005160

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