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Article

Cys-Cys cross-linking shows contact between the N-terminus of lethal factor and Phe427 of the anthrax toxin pore.

Biochemistry - 3 May 2011

Janowiak Blythe E, Jennings-Antipov Laura D, Collier R John

Abstract excerpt

Electrophysiological studies of wild-type and mutated forms of anthrax protective antigen (PA) suggest that the Phe clamp, a structure formed by the Phe427 residues within the lumen of the oligomeric PA pore, binds the unstructured N-terminus of the lethal factor and the edema factor during initiation of translocation. We now show by electrophysiological measurements and gel shift assays that a single Cys...

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Identifiers

PMID: 21425869
DOI: 10.1021/bi1017446
PMCID: PMC3082969

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Source receipt: pubmed, retrieved 7 Sept 2026.

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