Dynamic gating by ϕ-clamp loop controls peptide translocation through the anthrax toxin nanopore.

Abstract excerpt

The ϕ clamp, a key active site in the anthrax toxin protective antigen (PA) nanopore, governs the complex process of peptide translocation, yet its precise mechanism remains debated. A key question is how might the nanopore mitigate the formation of too stable/static of a ϕ-clamp interaction with the polymer it is attempting to translocate. One hypothesis is that it would "gate" to bind and "ungate" to release....

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