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Article

Evidence that the COMTVal158Met polymorphism moderates subclinical psychotic and affective symptoms in unaffected first-degree relatives of patients with schizophrenia.

European psychiatry : the journal of the Association of European Psychiatrists - 1 Apr 2008

van Winkel Ruud, Isusi Pilar, Galdos Paloma, Echevarria Elena, Bilbao José Ramón, Martin-Pagola Ainhoa, Castaño Luis, Papiol Sergi, Mengelers Ron, Krabbendam Lydia, van Os Jim, Myin-Germeys Inez

Abstract excerpt

OBJECTIVES: Psychotic patients with COMT(Val158Met) Met alleles were recently found to display more intense psychotic and affective responses to daily life stressors. We aimed to test the hypothesis that the Met allele is implicated in the development of affective and psychotic symptomatology in...

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Source

Identifiers

PMID: 18328676
DOI: 10.1016/j.eurpsy.2007.12.002

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18328676-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Evidence that the COMTVal158Met polymorphism moderates subclinical psychotic and affective symptoms in unaffected first-degree relatives of patients with schizophrenia.PMID 18328676Read ↗

Differential association of the COMT Val158Met polymorphism with clinical phenotypes in schizophrenia and bipolar disorder.Semantic proximity Read ↗

COMT Val158Met moderation of stress-induced psychosis.Semantic proximity Read ↗

COMT Val(158)Met genotype and cannabis use in people with an At Risk Mental State for psychosis: Exploring Gene x Environment interactions.Semantic proximity Read ↗

COMT Val158Met-stress interaction in psychosis: role of background psychosis risk.Semantic proximity Read ↗

Effect of COMT genotype on aggressive behaviour in a community cohort of schizophrenic patients.Semantic proximity Read ↗

Catechol-O-methyltransferase and the clinical features of psychosis.Semantic proximity Read ↗

Evidence that interactive effects of COMT and MTHFR moderate psychotic response to environmental stress.Semantic proximity Read ↗

Associations between COMTVal158Met polymorphism and cognition: direct or indirect effects?Semantic proximity Read ↗

Relationship between the COMT-Val158Met and BDNF-Val66Met polymorphisms, childhood trauma and psychotic experiences in an adolescent general population sample.Semantic proximity Read ↗

A meta-analysis of the Val158Met COMT polymorphism and violent behavior in schizophrenia.Semantic proximity Read ↗

Subclinical psychotic experiences in healthy young adults: associations with stress and genetic predisposition.Semantic proximity Read ↗

Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia.Semantic proximity Read ↗

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