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Article

Evidence that interactive effects of COMT and MTHFR moderate psychotic response to environmental stress.

Acta psychiatrica Scandinavica - 1 Mar 2012

Peerbooms O, Rutten B P F, Collip D, Lardinois M, Lataster T, Thewissen V, Rad S Mafi, Drukker M, Kenis G, van Os J, Myin-Germeys I, van Winkel R

Abstract excerpt

OBJECTIVE: A functional interaction between Catechol-O-Methyltransferase (COMT) Val158Met and methylenetetrahydrofolate reductase (MTHFR) C677T has been shown to differentially affect cognition in patients with schizophrenia and healthy controls; the effect of COMT Val158Met × MTHFR interaction on resilience to stress in patients and controls remains to be examined. METHOD: A total of 98 patients with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22128864
DOI: 10.1111/j.1600-0447.2011.01806.x

Genes

MTHFR
COMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Evidence that interactive effects of COMT and MTHFR moderate psychotic response to environmental stress.PMID 22128864Read ↗

COMT Val158Met-stress interaction in psychosis: role of background psychosis risk.Semantic proximity Read ↗

Evidence that the COMT(Val158Met) polymorphism moderates sensitivity to stress in psychosis: an experience-sampling study.Semantic proximity Read ↗

COMT Val158Met moderation of stress-induced psychosis.Semantic proximity Read ↗

COMT ValMet moderation of cannabis-induced psychosis: a momentary assessment study of 'switching on' hallucinations in the flow of daily life.Semantic proximity Read ↗

Joint Impact of Early Life Adversity and COMT Val158Met (rs4680) Genotypes on the Adult Cortisol Response to Psychological Stress.Semantic proximity Read ↗

Stressful life events and catechol-O-methyl-transferase (COMT ) gene in bipolar disorderSemantic proximity Read ↗

Children under stress - COMT genotype and stressful life events predict cortisol increase in an acute social stress paradigm.Semantic proximity Read ↗

Stress, COMT Polymorphisms, and Depressive Symptoms in Older Australian Women: An Exploratory Study.Semantic proximity Read ↗

The interaction of early life experiences with COMT val158met affects anxiety sensitivity.Semantic proximity Read ↗

Early‐Life Adversity and Blunted Stress Reactivity as Predictors of Alcohol and Drug use in Persons With COMT (rs4680) Val158Met GenotypesSemantic proximity Read ↗

An experimental study of catechol-o-methyltransferase Val158Met moderation of delta-9-tetrahydrocannabinol-induced effects on psychosis and cognition.Semantic proximity Read ↗

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