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Article

COMT Val158Met moderation of stress-induced psychosis.

Psychological medicine - 1 Nov 2007

Stefanis Nicholas C, Henquet Cécile, Avramopoulos Dimitrios, Smyrnis Nikolaos, Evdokimidis Ioannis, Myin-Germeys Inez, Stefanis Costas N, Van Os Jim

Abstract excerpt

BACKGROUND: Exposure to stressful life events increases the risk of developing a psychotic disorder. Moreover, increased reactivity to stress seems to represent part of the vulnerability for psychosis. This study aimed to investigate whether a functional polymorphism in the catechol-O-methyltransferase (COMT Val(158)Met) gene moderates the psychosis-inducing effects of stress. METHOD: A semi-experimental stress...

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Source

Identifiers

PMID: 17640440
DOI: 10.1017/S0033291707001080

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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COMT Val158Met moderation of stress-induced psychosis.PMID 17640440Read ↗

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COMT Val158Met genotype selectively alters prefrontal [18F]fallypride displacement and subjective feelings of stress in response to a psychosocial stress challenge.Semantic proximity Read ↗

The risk of posttraumatic stress disorder after trauma depends on traumatic load and the catechol-o-methyltransferase Val(158)Met polymorphism.Semantic proximity Read ↗

Stress, COMT Polymorphisms, and Depressive Symptoms in Older Australian Women: An Exploratory Study.Semantic proximity Read ↗

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Relationship between the COMT-Val158Met and BDNF-Val66Met polymorphisms, childhood trauma and psychotic experiences in an adolescent general population sample.Semantic proximity Read ↗

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