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Alternatives to the carcinogenicity bioassay:<i>in silico</i>methods, and the<i>in vitro</i>and<i>in vivo</i>mutagenicity assays

3 May 2010

Abstract excerpt

IMPORTANCE OF THE FIELD: Carcinogenicity and mutagenicity are toxicological end points posing considerable concern for human health. Due to the cost in animal lives, time and money, alternative approaches to the rodent bioassay were designed based on: i) identification of mutations and ii) structure-activity relationships. AREAS COVERED IN THIS REVIEW: Evidence on i) and ii) is summarized, covering 4 decades...

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PMID: 20438313
DOI: 10.1517/17425255.2010.486400

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