Article
Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT).
Environmental and molecular mutagenesis - 1 Dec 2025
Parsons Barbara L, Beal Marc A, Dearfield Kerry L, Douglas George R, Gi Min, Gollapudi B Bhaskar, Heflich Robert H, Horibata Katsuyoshi, Kenyon Michelle, Long Alexandra S, Lovell David P, Lynch Anthony M, Myers Meagan B, Pfuhler Stefan, Vespa Alisa, Zeller Andreas, Johnson George E, White Paul A
Abstract excerpt
Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose-response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An "effect severity" AF (ESAF) is employed in some regulatory contexts. An ESAF of 10 may be incorporated in the derivation of a health-based guidance value (HBGV) when a "severe" toxicological endpoint, such as...
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