Mechanistic data and cancer risk assessment: the need for quantitative molecular endpoints.

doi:10.1002/em.20093

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Article

Mechanistic data and cancer risk assessment: the need for quantitative molecular endpoints.

Environmental and molecular mutagenesis - 1 Jan 2000

Preston R Julian

Abstract excerpt

The cancer risk assessment process as currently proposed by the U.S. Environmental Protection Agency allows for the use of mechanistic data to inform the low-dose tumor response in humans and in laboratory animals. The aim is to reduce the reliance on defaults that introduce a relatively high level of uncertainty to the risk estimates. The types of data required for this purpose are those that help identify key...

Topics

Biomarkers, Tumor
Carcinogenicity Tests
Carcinogens, Environmental
Dose-Response Relationship, Drug
Endpoint Determination
Genomics
Humans
Mutation
Neoplasms
Oligonucleotide Array Sequence Analysis
Proteomics
Risk Assessment
United States
United States Environmental Protection Agency

Source

Open in PubMed

Identifiers

PMID: 15645441
DOI: 10.1002/em.20093

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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