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Article

Mechanistic data and cancer risk assessment: the need for quantitative molecular endpoints.

Environmental and molecular mutagenesis - 1 Jan 2000

Preston R Julian

Abstract excerpt

The cancer risk assessment process as currently proposed by the U.S. Environmental Protection Agency allows for the use of mechanistic data to inform the low-dose tumor response in humans and in laboratory animals. The aim is to reduce the reliance on defaults that introduce a relatively high level of uncertainty to the risk estimates. The types of data required for this purpose are those that help identify key...

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PMID: 15645441
DOI: 10.1002/em.20093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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