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Article

Modernizing Human Cancer Risk Assessment of Therapeutics.

Trends in pharmacological sciences - 1 Mar 2018

Fielden Mark R, Ward Lucas D, Minocherhomji Sheroy, Nioi Paul, Lebrec Herve, Jacobson-Kram David

Abstract excerpt

Cancer risk assessment of therapeutics is plagued by poor translatability of rodent models of carcinogenesis. In order to overcome this fundamental limitation, new approaches are needed that enable us to evaluate cancer risk directly in humans and human-based cellular models. Our enhanced understanding of the mechanisms of carcinogenesis and the influence of human genome sequence variation on cancer risk...

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Identifiers

PMID: 29242029
DOI: 10.1016/j.tips.2017.11.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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