Article
Mutational spectrometry in animal toxicity testing.
Annual review of pharmacology and toxicology - 1 Jan 1990
Thilly W G
Abstract excerpt
The microbial geneticists who pioneered the study of mutational spectra have shown us how rich a source of mutagen-specific information it can be for the pharmacologist and toxicologist. Contributions by physical chemists and molecular biologists have led to a practical means to observe mutation spectra directly from the DNA of cultured human cells and this review suggests that the same methodology may be applied...
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