Article
Cancer risk assessment at the crossroads: the need to turn to a biological approach.
Regulatory toxicology and pharmacology : RTP - 1 Aug 1996
Clayson D B, Iverson F
Abstract excerpt
Mathematically based carcinogen risk assessment is based on a number of prudent default assumptions which are becoming progressively less tenable as new scientific evidence is adduced. For example, the assumptions that all rodent carcinogens will be carcinogenic in humans and that there is no safe dose of any carcinogen may, in specific examples, be shown to be untrue. The mechanisms by which carcinogens exert...
Topics
- Animals
- Carcinogens
- DNA Damage
- DNA Repair
- Humans
- Models, Theoretical
- Mutation
- Neoplasms, Experimental
- Quality Control
- Risk Assessment
- Rodentia