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Article

Mice lacking the transcription factor Ikaros display behavioral alterations of an anti-depressive phenotype.

Experimental neurology - 1 May 2008

Kiehl Tim-Rasmus, Fischer Sandra E, Ezzat Shereen, Asa Sylvia L

Abstract excerpt

The Ikaros (Ik) family of transcription factors has critical functions in immune regulation, lymphohematopoiesis and the hypothalamic-pituitary axis. Ik influences cell fate decisions through transcriptional activation of target genes and its interaction with chromatin remodeling complexes. While Ik is well-described in the lymphoid system and pituitary, its presence and function in the brain has received limited...

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Identifiers

PMID: 18313668
DOI: 10.1016/j.expneurol.2008.01.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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