Article
A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma.
Cell - 20 Oct 1995
Winandy S, Wu P, Georgopoulos K
Abstract excerpt
The Ikaros gene is essential for lymphoid lineage specification. As previously reported, mice homozygous for a mutation in the Ikaros DNA-binding domain fail to generate mature lymphocytes as well as their earliest described progenitors. In addition, our studies with mice heterozygous for this mu...
Topics
- Animals
- Base Sequence
- Cell Differentiation
- Clone Cells
- DNA-Binding Proteins
- Genes, Dominant
- Hematopoietic Stem Cells
- Heterozygote
- Homeostasis
- Ikaros Transcription Factor
- Leukemia, T-Cell
- Lymphocyte Activation
- Lymphoid Tissue
- Lymphoma, T-Cell
- Lymphoproliferative Disorders
- Mice
- Mice, Mutant Strains
- Models, Immunological