Article
A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma.
Cell - 20 Oct 1995
Winandy S, Wu P, Georgopoulos K
Abstract excerpt
The Ikaros gene is essential for lymphoid lineage specification. As previously reported, mice homozygous for a mutation in the Ikaros DNA-binding domain fail to generate mature lymphocytes as well as their earliest described progenitors. In addition, our studies with mice heterozygous for this mutation establish the Ikaros gene as an essential regulator of T cell proliferation. Thymocytes display augmented...
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