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Article

Ikaros is critical for B cell differentiation and function.

European journal of immunology - 1 Mar 2002

Kirstetter Peggy, Thomas Mireille, Dierich Andrée, Kastner Philippe, Chan Susan

Abstract excerpt

The Ikaros gene encodes a zinc-finger transcription factor required during early B cell development, as B-lineage cells are absent in mice lacking Ikaros. Here we describe a novel Ikaros-targeted mouse line carrying a beta-galactosidase reporter in which low amounts of Ikaros proteins remain expressed. In homozygote animals, B cells are absent during fetal development, but develop postnatally from a reduced pool...

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Source

Identifiers

PMID: 11870616
DOI: 10.1002/1521-4141(200203)32:3<720::AID-IMMU720>3.0.CO;2-P

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ikaros is critical for B cell differentiation and function.PMID 11870616Read ↗

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The role of the Ikaros gene in lymphocyte development and homeostasis.Semantic proximity Read ↗

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Lack of Ikaros Deregulates Inflammatory Gene Programs in T CellsSemantic proximity Read ↗

Aiolos regulates B cell activation and maturation to effector state.Semantic proximity Read ↗

Defects in hemopoietic stem cell activity in Ikaros mutant mice.Semantic proximity Read ↗

Ikaros is absolutely required for pre-B cell differentiation by attenuating IL-7 signals.Semantic proximity Read ↗

Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development.Semantic proximity Read ↗

Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor.Semantic proximity Read ↗

The ikaros gene is required for the development of all lymphoid lineagesSemantic proximity Read ↗

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