Article
TNiK is required for postsynaptic and nuclear signaling pathways and cognitive function.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Oct 2012
Coba Marcelo P, Komiyama Noboru H, Nithianantharajah Jess, Kopanitsa Maksym V, Indersmitten Tim, Skene Nathan G, Tuck Ellie J, Fricker David G, Elsegood Kathryn A, Stanford Lianne E, Afinowi Nurudeen O, Saksida Lisa M, Bussey Timothy J, O'Dell Thomas J, Grant Seth G N
Abstract excerpt
Traf2 and NcK interacting kinase (TNiK) contains serine-threonine kinase and scaffold domains and has been implicated in cell proliferation and glutamate receptor regulation in vitro. Here we report its role in vivo using mice carrying a knock-out mutation. TNiK binds protein complexes in the synapse linking it to the NMDA receptor (NMDAR) via AKAP9. NMDAR and metabotropic receptors bidirectionally regulate TNiK...
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