Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development.

The EMBO journal - 1 Oct 1996

Sun L, Liu A, Georgopoulos K

Abstract excerpt

The Ikaros gene, an essential regulator of lymphocyte differentiation, encodes, by means of differential splicing, protein isoforms with a distinct number of Kruppel-type zinc fingers organized in two domains. Deletion of the N-terminal zinc finger domain responsible for the sequence-specific DNA...

Topics

3T3 Cells
Amino Acid Sequence
Animals
Cell Differentiation
Cell Line
Cell Nucleus
Chelating Agents
DNA
DNA-Binding Proteins
Dimerization
Egtazic Acid
Ikaros Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocytes

Mice

Molecular Sequence Data

Mutation

Protein Binding

Recombinant Fusion Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 8895580
PMCID: PMC452279

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8895580-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development.PMID 8895580Read ↗

The role of the Ikaros gene in lymphocyte development and homeostasis.Semantic proximity Read ↗

Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros.Semantic proximity Read ↗

A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma.Semantic proximity Read ↗

Expression of dominant-negative Ikaros isoforms in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Ikaros is critical for B cell differentiation and function.Semantic proximity Read ↗

Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor.Semantic proximity Read ↗

The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouseSemantic proximity Read ↗

Regulator of myeloid differentiation and function: The secret life of IkarosSemantic proximity Read ↗

Conserved helical motifs in the Ikaros IDR mediate NuRD interaction and transcriptional repressionSemantic proximity Read ↗

Lack of Ikaros Deregulates Inflammatory Gene Programs in T CellsSemantic proximity Read ↗

The ikaros gene is required for the development of all lymphoid lineagesSemantic proximity Read ↗

Human Ikaros Function in Activated T Cells Is Regulated by Coordinated Expression of Its Largest IsoformsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.