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Article

The role of the Ikaros gene in lymphocyte development and homeostasis.

Annual review of immunology - 1 Jan 1997

Georgopoulos K, Winandy S, Avitahl N

Abstract excerpt

The Ikaros gene, which encodes a family of hemopoietic-specific zinc finger proteins, is described as a central regulator of lymphocyte differentiation. During fetal development, it is required at the earliest stage of T cell and B cell specification. In the adult, however, lymphoid lineages rely on Ikaros at distinct phases of their development. Its activity is essential for the generation of B cell but not of T...

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Identifiers

PMID: 9143685
DOI: 10.1146/annurev.immunol.15.1.155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The role of the Ikaros gene in lymphocyte development and homeostasis.PMID 9143685Read ↗

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