Article
The role of the Ikaros gene in lymphocyte development and homeostasis.
Annual review of immunology - 1 Jan 1997
Georgopoulos K, Winandy S, Avitahl N
Abstract excerpt
The Ikaros gene, which encodes a family of hemopoietic-specific zinc finger proteins, is described as a central regulator of lymphocyte differentiation. During fetal development, it is required at the earliest stage of T cell and B cell specification. In the adult, however, lymphoid lineages rely...
Topics
- Adult
- Animals
- Cell Differentiation
- DNA-Binding Proteins
- Genes, Tumor Suppressor
- Hematopoiesis
- Homeostasis
- Humans
- Ikaros Transcription Factor
- Lymphocytes
- Models, Biological
- Mutation
- T-Lymphocytes
- Trans-Activators
- Transcription Factors
- Zinc Fingers