Article

Dek Loss Induces Sex-Dependent, Task-Specific Cognitive Deficits and Reprograms the Hippocampal Transcriptome in Mice

2025-10-17

Abstract excerpt

<title>Abstract</title> <p> Cognitive decline with aging, and some neurodegenerative conditions like Alzheimer’s disease, disproportionately affects females yet few mechanisms beyond steroid hormone signaling fully explain this sex-specific vulnerability. The chromatin-remodeling DEK protein, upregulated by estrogen and progesterone and broadly expressed in the brain, including the hippocampus, may be one such m...

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Literature Corpus work: 0ff9466e-f0d5-5f8d-8eb1-240deab00716
DOI: 10.21203/rs.3.rs-7577113/v1

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