Article
Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor.
Immunity - 1 Jul 2003
Papathanasiou Peter, Perkins Andrew C, Cobb Bradley S, Ferrini Roger, Sridharan Rupa, Hoyne Gerard F, Nelms Keats A, Smale Stephen T, Goodnow Christopher C
Abstract excerpt
A central issue in understanding the hematolymphoid system is the generation of appropriate mutant alleles in mice to reveal the function of regulatory genes. Here we describe a mouse strain, Plastic, with a point mutation in a zinc finger of Ikaros that disrupts DNA binding but preserves efficient assembly of the full-length protein into higher order complexes. Ikaros(Plastic) homozygosity is embryonically...
Topics
- Alleles
- Anemia
- Animals
- Cell Differentiation
- DNA
- DNA-Binding Proteins
- Dimerization
- Erythrocytes
- Ethylnitrosourea
- Hematopoiesis
- Hepatocytes
- Ikaros Transcription Factor
- Lymphocytes